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Multum drug information does not endorse drugs, diagnose patients or recommend therapy. Pioglitazone sold as Actos drug in the same family as Avandia, is uber glipizide not recommended, as Public Citizen study shows it has liver toxicity risks similar to its 10 cases of death from Actos-related liver failure were found in the study. For patients whose daily insulin requirement is greater than 20 units, the insulin dose should be reduced by 50 and Glipizide therapy may begin at usual dosages. How should take glipizide? Take glipizide exactly as directed by your doctor.